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For other references to Circos usage and items of note, see examples of published images and Circos citations.

News



31 October 2013

Circos reaches a milestone - 500 citations in peer-reviewed literature. To celebrate, I've made a commemorative poster that features over 400 Circos images from the literature.

citation list | image gallery | press highlights

Circos poster - 500 citations (400 x 517)
Circos reaches 500 citations in scientific literature.
30 October 2013

Boo! Circos appears on the cover of the Genome Informatics 2013 conference. The image is taken from Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.) by Ming et al..

I had the opportunity to design the cover for the conference a few years back. The Genome Informatics 2010 cover showed a unique depiction of gene sequences mentioned in the abstract book.

Circos poster - 500 citations (300 x 474)
Circos on the cover of Genome Informatics 2013 program cover.
1 January 2013

Circos appears on the cover of Nature Review's 2013 Cancer Calendar in the form of a figure taken from

Shih AH, Abdel-Wahab O, Patel JP et al. 2012 The role of mutations in epigenetic regulators in myeloid malignancies Nat Rev Cancer 12:599-612.

Nature Reviews recognizes the importance of clear and informative figures:

"Indeed, given the adage that 'a picture paints a thousand words', good figures can encapsulate entire fields of cancer research without the need for extensive explanations."

Circos - Circular Genome Data Visualization (400 x 357)
8 December 2010

A Circos figure appears on the cover of Science Translational Medicine. I'm very happy to report that with this cover, Circos has appeared on the covers of both Nature and Science publications, the world's two top scientific journals.

Circos on the cover of Science Translational Medicine (310 x 427)
14 April 2010

Nature features an article by Heidi Ledford, The Cancer Genome Challenge, which uses Circos images from the COSMIC project to illustrate the landscape of structural variation in cancer.

Circos image in Nature - The Cancer Genome Challenge (969 x 431)
6Ledford H 2010 Big science: The cancer genome challenge Nature 464 (7291) 972-974.
1 March 2010

In a technology feature, Epigenome: mapping in motion, Monya Baker describes the current state of epigenetics and the search for epigenetic biological markers (1Baker M 2010 Epigenome: Mapping in Motion Nature Methods 7 (3) 181-186.).

The feature cites an article I wrote with Costello and Marra about epigenetics A first look at entire human methylomes, that included a figure I designed to show the richness of whole-genome epigenetic data and its variation across tissues.

Circos illustrates whole-genome epigenetic data (300 x 390)
Image from
24Costello JF, Krzywinski M, Marra MA 2009 A first look at entire human methylomes Nature biotechnology 27 (12) 1130-1132.
3 November 2009

An illustration of genome annotations of the E coli genome appears on the cover of Nature Biotechnology (vol 27, no 11). The image accompanies the article The transcription unit architecture of the Escherichia coli genome by Cho et al.

Circos image in Nature Biotechnology - Escherichia Coli (300 x 395)
23Cho BK, Zengler K, Qiu Y et al. 2009 The transcription unit architecture of the Escherichia coli genome Nature biotechnology 27 (11) 1043-1049.
18 June 2009

Circos is published in Genome Research. The paper comes with an attractive foldout poster! To cite circos, please use

Krzywinski, M. et al. Circos: an Information Aesthetic for Comparative Genomes. Genome Res (2009) 19:1639-1645.

Download the Endnote reference

Circos: an Information Aesthetic for Comparative Genomics. (971 x 240)
Figures 1, 2, 7 and 8 from Krzywinski, M. et al. Circos: an Information Aesthetic for Comparative Genomes. Genome Res (2009) 19:1639-1645.

ABSTRACT We created a visualization tool, called Circos, to facilitate the identification and analysis of similarities and differences arising from comparisons of genomes. Our tool is effective in displaying variation in genome structure and, generally, any other kind of positional relationships between genomic intervals. Such data are routinely produced by sequence alignments, hybridization arrays, genome mapping, and genotyping studies. Circos uses a circular ideogram layout to facilitate the display of relationships between pairs of positions by the use of ribbons, which encode the position, size, and orientation of related genomic elements. Circos is capable of displaying data as scatter, line and histogram plots, heat maps, tiles, connectors and text. Bitmap or vector images can be created from GFF-style data inputs and hierarchical configuration files, which can be easily generated by automated tools, making Circos suitable for rapid deployment in data analysis and reporting pipelines.

13 May 2009

An image created by Circos appears on the cover of the EMBO Journal (6 May 2009, vol 28, no 9). The image is a crop of a comparison of 4 genomes (human, chimp, mouse and zebrafish) which is available at full resolution as part of a poster.

Circos image on EMBO Journal cover (394 x 517)
Cover of The Embo Journal (6 May 2009, vol 28, no 9).
15 October 2008

Circos is being used in the Catalogue of Somatic Mutations in Cancer (COSMIC) to show structural variation and copy number changes.

Circos in COSMIC (400 x 198)
27Forbes SA, Tang G, Bindal N et al. 2009 COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer Nucleic Acids Res 38 (Database issue) D652-657.
3 September 2008

A visual guide to Circos (Circos - an information aesthetic for comparative genomics) will be presented at the Genome Informatics meeting in Hinxton, UK (September 10-14, 2008). The guide presents some of the capabilities of Circos and its application in the field of comparative genomics and genome visualization.

Download: medium bitmap (7Mb) | huge bitmap (46Mb) | PDF (40Mb) | Illustrator (20Mb)

Circos - an information aesthetic for comparative genomics - presented at Genome Informatics 2008, Hinxton, UK (600 x 372)
27 April 2008
9 August 2007

Circos appears on the cover of American Scientist (Sept/Oct issue). The image accompanies the article Genetics and the Shape of Dogs by Elaine Ostrander. Read about the figure.

Circos - Circular Genome Data Visualization (400 x 490)
9 November 2006

Circos used in Nature publication Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia by J.M. Aury et al. The image

This unusual, but effective, Circos image shows successive duplications in the Paramecium genome. The exterior circle displays all chromosome-sized scaffolds, and the three interior circles show the reconstructed sequences obtained by fusion of the paired sequences from each previous step.

Circos - Circular Genome Data Visualization (400 x 400)
57Aury JM, Jaillon O, Duret L et al. 2006 Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia Nature 444 (7116) 171-178.