Circos > Guide > Genomic

Guide to Displaying Sequence Conservation Across Species

This poster shows how Circos can be used to display sequence similarity and conservation. The inner ribbon track is used to show synteny and exterior tracks quantify the degree of sequence conservation between the human genome and 7 other species.

This guide demonstrates the use of the convential chromosome color palette, in which each of the human chromosomes, as well as well as chrUn (unanchored sequence), is assigned a characteristic color. Also shown are ways in which 2D track types (text, stacked histogram, highlight, heatmap) can be used to add texture to the data or display summary statistics.

An example of how sequence similarity and conservation can be shown. In the figure the entire human genome and three dog chromosomes are displayed. The dog chromosomes are inserted within the progression of human chromosomes, which helps separate the ribbons that are used to show synteny. (zoom).