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Circos at the EMBO NGS workshop in Tunis, Sept 15–25.

Circos on Cancer Discovery Covers

The July 2013 issue cover shows a Circos plot of relative copy number changes in 38 oral squamous cell carcinoma tumors.

The September 2012 issue cover shows a collection of Circos images of somatic mutations in melanoma tumors.

July 2013 Pickering CR, Zhang J, Yoo SY et al. 2013 Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers Cancer discovery 3:770-781.

Sep 2012 Dahlman KB, Xia J, Hutchinson K et al. 2012 BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors Cancer discovery 2:791-797.

Circos charts the placenta transcriptome

Saben et al. use Circos to visualize the transcriptome and gene expression of placenta from 20 healthy women in their article A comprehensive analysis of the human placenta transcriptome.

Saben J, Zhong Y, McKelvey S et al. 2014 A comprehensive analysis of the human placenta transcriptome Placenta 35:125-131.

Circos on cover of UCSF Magazine

The Fall 2013 issue of UCSF Magazine has my Circos illustration of personalized medicine. The human outline motif is incorporated into other design elements in the issue.

The look of the image is inspired after Nature's Encode cover by Carl De Torres.

To learn how to generate the cover and variants, read the Circos Encode Cover Tutorial.

Circos on Cover of Biotechnology Focus

Circos appears on the cover of the Dec 2012 / Jan 2013 issue of Biotechnology Focus, a magazine about the Life Sciences sector in Canada.

The image is part of an article about epigenomics, which includes other graphics work I've done for the Genome Sciences Center.

"One of the biggest breakthroughs so far in the war on cancer was the realization that it is essentially a genetic disease. However, as we learn more about cancer, it becomes clearer that what’s written in our DNA is only part of the story; there are other factors at work that go beyond genetics."

Circos on Cover of Cancer Cell

Yang et al. used network analysis approaches characterize a subtype of ovarian cancer associated with poor overall survival.

E-cadherin is a protein encoded by the CDH1 gene and is responsible for cell-cell adhesion. Yang linked the expression of E-cadherin to specific miRNAs that influenced the regulatory network singled out in this cancer subtype.

Yang D, Sun Y, Hu L et al. 2013 Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer Cancer cell 23:186-199

Circos Round — Lotus Sacred

The pleasing roundness of Circos is used by Ming et al. to depict the Sacred Lotus genome in the publication "Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.).

The Sacred lotus has religious significance in both Buddhism and Hinduism and has been used as a food and herbal medicine product in Asia for over 7,000 years. Its seeds have exceptional longevity, remaining viable for as long as 1,300 years.

The plant is known for its exceptional water repellency, known as the lotus effect. The latter property is due to the nanoscopic closely packed protuberances of its self-cleaning leaf surface, which have been adapted for the manufacture of a self-cleaning industrial paint, Lotusan.

Ming R, Vanburen R, Liu Y et al. 2013 Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.) Genome Biol 14:R41.

Plants Love Circos

Circos frequently appears in plant literature, twice on the cover of Plant Biotechnology Journal in the last year.

Rai KM, Singh SK, Bhardwaj A et al. 2013 Large-scale resource development in Gossypium hirsutum L. by 454 sequencing of genic-enriched libraries from six diverse genotypes Plant biotechnology journal

Bekele WA, Wieckhorst S, Friedt W et al. 2013 High-throughput genomics in sorghum: from whole-genome resequencing to a SNP screening array Plant biotechnology journal

Circos has appeared 8 times each in the Plant Journal and Plant Cell.

Circos on the Cover Of Journal of Pathology

The June 2013 issue of the Journal of Pathology features a pair of Circos plots on the cover. The images are from the paper by Weier et al. describing TMPRSS2 and ERG rearrangements in prostate cancer.

"TMPRSS2–ERG rearrangements occur in approximately 50% of prostate cancers and therefore represent one of the most frequently observed structural rearrangements in all cancers."

Weier C, Haffner MC, Mosbruger T et al. 2013 Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer J Pathol 230:174-183.

Circos on the Cover Of Nature's Asian Journal of Andrology

The May 2013 Special Issue of Asian Journal of Andrology presents the outcomes from the Sixth Annual Forum on Prostate Disease (6th FPD), which was held on June 8-9, 2012 in Shanghai, China [source: nature.com]. The cover art for the issue shows a Circos plot of 90 significantly recurrent molecular alterations in prostate cancer from an analysis of 372 prostate tumors discussed in the Wyatt et al. review article.

The review summarizes the current state of understanding of prostate cancer, "including the sentinel role of copy number variation, the growing spectrum of oncogenic fusion genes, the potential influence of chromothripsis, and breakthroughs in defining mutation-associated subtypes. Increasing evidence suggests that genomic lesions frequently converge on specific cellular functions and signalling pathways, yet recurrent gene aberration appears rare".

Wyatt AW, Mo F, Wang Y et al. 2013 The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing Asian J Androl 15:301-308.

Brain Volume in Epilepsy

Pardoe et al. find that "Sodium valproate use in epilepsy is associated with parietal lobe thinning, reduced total brain volume, and reduced white matter volume."

The cover image shows antiepileptic drug combinations in intractable focal epilepsy cases. Linked drugs were being taken concurrently by an individual. Valproate cases are highlighted in orange.

Pardoe, HR, Berg, AT, and Jackson, GD 2013Sodium valproate use is associated with reduced parietal lobe thickness and brain volume Neurology 80(20):1895-1900.

Trends in Genetics Cover

Circos-based illustrator designed for the cover of Trends in Genetics human genetics special issue (Trends in Genetics October 2012, 28 (10)).

Read about how it was made.

Circle of Cancer

This Circos depiction of a tumor genome provides the cover of 30 November 2011 Science's Transitional Medicine issue in which Roychowdhury et al. describe personalized treatment for patients with colorectal and prostate cancer. By quickly sequencing normal and tumor DNA and RNA, suitable therapies can be tailored for the specific mutations identified.

1Roychowdhury S, Iyer MK, Robinson DR et al. 2011 Personalized Oncology Through Integrative High-Throughput Sequencing: A Pilot Study Science Translational Medicine 3:111ra121.

Circos Helps Universal Knowledge

Circos appears in Designing Universal Knowledge (buy at Amazon), a compilation of infographic methods by Gerlinde Schuller.

Circos Used in a David Cronenberg project about

In collaboration with Volumina, Circos was used to generate illustrations for Chromosomes exhibition, which toured in Rome, Turin and Lisbon.

Chromosomes is a David Cronenberg project which presents 70 images from his films, each accompanied by a text piece written by people from the world of art and science. I had the opportunity to contribute text to accompany the red bathtub photo.

The artbook is available for sale.

Little Fly, Thy Summer's Play...

In a collaboration with Derek Baccus from Pearson Science, Martin Krzywinski designed the cover illustration for the 3rd edition of iGenetics by Peter Russell.

The cover image shows a comparison of human and fruit fly genomes. The links indicate orthologous genes — genes in both genomes whose proteins are similar.

This cover won the cover award at 39th Annual 2009 Bookbuilders West Book Show.

Circos Appears on the Cover of Nature Biotechnology

An illustration of genome annotations of the E coli genome appears on the cover of Nature Biotechnology (vol 27, no 11). The image accompanies the article The transcription unit architecture of the Escherichia coli genome by Cho et al.

23Cho BK, Zengler K, Qiu Y et al. 2009 The transcription unit architecture of the Escherichia coli genome Nature biotechnology 27 (11) 1043-1049.

Oxford Biology Uses Circos for Book Cover

A Circos image designed by Martin Krzywinski appears on the cover of Building Bioformatics Solutions with Perl, R and MySQL by Conrad Bessant, Ian Shadforth, and Darren Oakley (Oxford Press).

Circos on The Embo Journal Cover

The Embo journal chooses a Circos image by Martin Krzywinski for its 6 May 2009 cover.

The image shows sequence similarity between human, chimp, mouse and zebrafish and is part of a poster that provides a visual tour of Circos.

Circos is a Bioinformatics Visualization Archetype

The Harvard School of Public Health uses a Circos image on its Bioinformatics Core Strategy Document.

The cover of the report shows three images that represent (a) raw data (genetic sequence), (b) computing resources to transmit and analyze the data (a network switch) and (c) summary and presentation of analysis (a Circos image).

For other references to Circos usage and items of note, see examples of published images and Circos citations.

News



11 February 2014

I just discovered a couple of Circos cover appearances in Cancer Discovery Journal.

The July 2013 issue cover shows a Circos plot of relative copy number changes in 38 oral squamous cell carcinoma tumors.

The September 2012 issue cover shows a collection of Circos images of somatic mutations in melanoma tumors.

Circos - Circular Genome Data Visualization (567 x 458)

July 2013 Pickering CR, Zhang J, Yoo SY et al. 2013 Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers Cancer discovery 3:770-781.

Circos - Circular Genome Data Visualization (567 x 456)

Sep 2012 Dahlman KB, Xia J, Hutchinson K et al. 2012 BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors Cancer discovery 2:791-797.

11 February 2014

Circos appears on the cover of Feb 2014 issue of Placenta Journal.

Saben J, Zhong Y, McKelvey S et al. 2014 A comprehensive analysis of the human placenta transcriptome Placenta 35:125-131.

Circos - Circular Genome Data Visualization (530 x 300)
22 November 2013

The Fall 2013 issue of UCSF Magazine has my Circos illustration of personalized medicine. The human outline motif is incorporated into other design elements in the issue.

The look of the image is inspired after Nature's Encode cover by Carl De Torres.

To learn how to generate the cover and variants, read the Circos Encode Cover Tutorial.

Circos image and design in Fall 2013 issue of UCSF magazine (702 x 813)
Circos image and design in Fall 2013 issue of UCSF magazine
30 October 2013

Boo! Circos appears on the cover of the Genome Informatics 2013 conference. The image is taken from Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.) by Ming et al..

I had the opportunity to design the cover for the conference a few years back. The Genome Informatics 2010 cover showed a unique depiction of gene sequences mentioned in the abstract book.

Circos poster - 500 citations (300 x 474)
Circos on the cover of Genome Informatics 2013 program cover.
8 March 2013

Circos appears on the cover of February 2013 issue of Genome Biology and Evolution. The image is taken from the paper

1Ahmed I, Biggs PJ, Matthews PJ et al. 2012 Mutational dynamics of aroid chloroplast genomes Genome Biol Evol 4:1316-1323.
Circos on the cover of Genome Biology and Evolution. (268 x 347)
1 January 2013

Circos appears on the cover of Jan 2013 issue of Biotechnology Focus in an article about epigenetics.

Circos - Circular Genome Data Visualization (317 x 428)
1 October 2012

Circos-based illustration designed for the cover of Trends in Genetics human genetics special issue (Trends in Genetics October 2012, 28 (10)).

Read about how it was made.

Circos - Circular Genome Data Visualization (400 x 523)
13 January 2011

Report on Business makes the connection between companies and perks in their January 2011 issue.

Circos on the cover of Report on Business (300 x 410)
8 December 2010

A Circos figure appears on the cover of Science Translational Medicine. I'm very happy to report that with this cover, Circos has appeared on the covers of both Nature and Science publications, the world's two top scientific journals.

Circos on the cover of Science Translational Medicine (310 x 427)
28 April 2010

In 2008, I worked with Pearson publishers to create a cover for iGenetics (3rd ed) by Peter Russell. I just received a copy of the award won by the book's cover illustration.

Circos iGenetics book cover - recognized at the 39th annual Bookbuilders West Book Show (781 x 400)
11 February 2010

Circos appears on the cover of Feb 11 2013 edition of Cancer Cell.

Yang D, Sun Y, Hu L et al. 2013 Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer Cancer cell 23:186-199

Circos - Circular Genome Data Visualization (400 x 523)
3 November 2009

An illustration of genome annotations of the E coli genome appears on the cover of Nature Biotechnology (vol 27, no 11). The image accompanies the article The transcription unit architecture of the Escherichia coli genome by Cho et al.

Circos image in Nature Biotechnology - Escherichia Coli (300 x 395)
23Cho BK, Zengler K, Qiu Y et al. 2009 The transcription unit architecture of the Escherichia coli genome Nature biotechnology 27 (11) 1043-1049.
13 May 2009

An image created by Circos appears on the cover of the EMBO Journal (6 May 2009, vol 28, no 9). The image is a crop of a comparison of 4 genomes (human, chimp, mouse and zebrafish) which is available at full resolution as part of a poster.

Circos image on EMBO Journal cover (394 x 517)
Cover of The Embo Journal (6 May 2009, vol 28, no 9).
7 January 2009

Circos appears in Designing Universal Knowledge (buy at Amazon), a compilation of infographic methods by Gerlinde Schuller.

Circos - Circular Genome Data Visualization (765 x 457)
1 December 2008

Circos is on the cover of Building Bioformatics Solutions with Perl, R and MySQL by Conrad Bessant, Ian Shadforth, and Darren Oakley (Oxford Press).

Building Bioformatics Solutions (344 x 450)
11 October 2008

In collaboration with Volumina, Circos was used to generate illustrations for Chromosomes exhibition, an art book of still images from David Cronenberg films.

Illustrations created with Circos used in Chromosomes, an exhibition by David Cronenberg. (500 x 508)

I had the opportunity to contribute not only the art work, but text for this book as well.

Illustrations created with Circos used in Chromosomes, an exhibition by David Cronenberg. (800 x 267)

We fear the unknown. Monsters and creatures are words we give to the most frightening unknown of all — the biological. Things living — primitive, unpredictable, ravenous and without recourse to emotion or reason. Clutching reason and humanity, we congratulate ourselves for having departed those base instincts.

But our departure is neither recent nor complete. Inside each of us is a history of our evolutionary ancestors, written in our chromosomes. The ant has 2. The house fly, 12. Humans have 46, a dog has 78 and in a fern, there are over 1,000. Chromosomes are the superblocks of genetic organization and heredity. They are an organism's contact list of its evolutionary ancestors.

Many of these ancestors were not different from monsters and creatures that inhabit our nightmares, our fears and our movies. And as the lights come on, and projections from the screen yield to reality, our body harbors elements from a darker past. Like the Alu genetic element, a jumping-gene which repeatedly copies itself within our genome and a constant companion to our evolution for the past 65 million years. In every part of every chromosome is our creature heritage.

Although we emerged in human from our mother's womb, as embryos we exhibited our evolutionary history: we all had gills, a tail, and body hair. Lost or absorbed before birth, these signposts remind us that our ancestors are inside us, not just in stories or movies. It is only later that the brain, our species' most prized possession, develops and transforms us. In the last minute, we pass into humanity and into the world. Today, we tell stories of monsters and creatures. Tomorrow, we may take their place. Distant from now, our progeny will see our forms during development and say "What creatures we were." Movies will frighten by showing our forms. "Look, mommy, a smooth-skinned biped with wide eyes."

2 October 2008

I worked with Pearson publishers to create a cover for iGenetics (3rd ed) by Peter Russell.

Circos book cover - iGenetics by Peter Russell, 3rd ed (331 x 450)
12 June 2008

American Scientist cover, which I created with Circos, wins Silver EXCEL Award in the Cover Illustration category from Society of National Association Publications (SNAP).

Circos - Circular Genome Data Visualization (150 x 184)

"The cover graphic is a dramatic visual representation of some of the chromosomal connections between the dog and human genomes," Schoonmaker said. "It helps readers understand how physical differences between dogs and humans, and between one dog and another, can be so large, even though they share much genetically." (more).

9 August 2007

Circos appears on the cover of American Scientist (Sept/Oct issue). The image accompanies the article Genetics and the Shape of Dogs by Elaine Ostrander. Read about the figure.

Circos - Circular Genome Data Visualization (400 x 490)