Circos on the Cover Of Journal of Pathology
"TMPRSS2–ERG rearrangements occur in approximately 50% of prostate cancers and therefore represent one of the most frequently observed structural rearrangements in all cancers."
2013 Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer J Pathol 230:174-183.
Circos on the Cover Of Nature's Asian Journal of Andrology
The May 2013 Special Issue of Asian Journal of Andrology presents the outcomes from the Sixth Annual Forum on Prostate Disease (6th FPD), which was held on June 8-9, 2012 in Shanghai, China [source: nature.com]. The cover art for the issue shows a Circos plot of 90 significantly recurrent molecular alterations in prostate cancer from an analysis of 372 prostate tumors discussed in the Wyatt et al. review article.
The review summarizes the current state of understanding of prostate cancer, "including the sentinel role of copy number variation, the growing spectrum of oncogenic fusion genes, the potential influence of chromothripsis, and breakthroughs in defining mutation-associated subtypes. Increasing evidence suggests that genomic lesions frequently converge on specific cellular functions and signalling pathways, yet recurrent gene aberration appears rare".
2013 The diverse heterogeneity of molecular alterations in prostate cancer identified through next-generation sequencing Asian J Androl 15:301-308.
Brain Volume in Epilepsy
Pardoe et al. find that "Sodium valproate use in epilepsy is associated with parietal lobe thinning, reduced total brain volume, and reduced white matter volume."
The cover image shows antiepileptic drug combinations in intractable focal epilepsy cases. Linked drugs were being taken concurrently by an individual. Valproate cases are highlighted in orange.
2013Sodium valproate use is associated with reduced parietal lobe thickness and brain volume Neurology 80(20):1895-1900.
Circos on Cover of Biotechnology Focus
Circos appears on the cover of the Dec 2012 / Jan 2013 issue of Biotechnology Focus, a magazine about the Life Sciences sector in Canada.
The image is part of an article about epigenomics, which includes other graphics work I've done for the Genome Sciences Center.
"One of the biggest breakthroughs so far in the war on cancer was the realization that it is essentially a genetic disease. However, as we learn more about cancer, it becomes clearer that what’s written in our DNA is only part of the story; there are other factors at work that go beyond genetics."
Circle of Cancer
This Circos depiction of a tumor genome provides the cover of 30 November 2011 Science's Transitional Medicine issue in which Roychowdhury et al. describe personalized treatment for patients with colorectal and prostate cancer. By quickly sequencing normal and tumor DNA and RNA, suitable therapies can be tailored for the specific mutations identified.
1 2011 Personalized Oncology Through Integrative High-Throughput Sequencing: A Pilot Study Science Translational Medicine 3:111ra121.
Circos Used in a David Cronenberg project about
Chromosomes is a David Cronenberg project which presents 70 images from his films, each accompanied by a text piece written by people from the world of art and science. I had the opportunity to contribute text to accompany the red bathtub photo.
The artbook is available for sale.
Little Fly, Thy Summer's Play...
The cover image shows a comparison of human and fruit fly genomes. The links indicate orthologous genes — genes in both genomes whose proteins are similar.
This cover won the cover award at 39th Annual 2009 Bookbuilders West Book Show.
Circos Takes a Train Ride
A Circos visualization is included as part of the Science Express project.
A public education effort lead by Max Planck institute, Science Express is a 13 car train, lavishly repurposed into a rolling interactive science exhibition. The purpose of the project is to raise and foster science awareness and education to the public.
Circos Appears on the Cover of Nature Biotechnology
An illustration of genome annotations of the E coli genome appears on the cover of Nature Biotechnology (vol 27, no 11). The image accompanies the article The transcription unit architecture of the Escherichia coli genome by Cho et al.23 2009 The transcription unit architecture of the Escherichia coli genome Nature biotechnology 27 (11) 1043-1049.
Oxford Biology Uses Circos for Book Cover
A Circos image designed by Martin Krzywinski appears on the cover of Building Bioformatics Solutions with Perl, R and MySQL by Conrad Bessant, Ian Shadforth, and Darren Oakley (Oxford Press).
Circos is a Bioinformatics Visualization Archetype
The Harvard School of Public Health uses a Circos image on its Bioinformatics Core Strategy Document.
The cover of the report shows three images that represent (a) raw data (genetic sequence), (b) computing resources to transmit and analyze the data (a network switch) and (c) summary and presentation of analysis (a Circos image).