Power of Round
Circular data tracks naturally support display of information at various resolutions.
Compared to a track at a radius r, a pixel in a track at r/4 will span a region 4x larger. Tracks in the interior of the figure are therefore useful to display low-resolution or summary information.
Dog vs Human Synteny Panel
The completion of the draft version of the dog genome revealed large overlaps between dog and human genomes. Working with American Scientist, Martin Krzywinski designed the cover image for the magazine's Sept/Oct 2007 issue, to accompany the article "Genetics and the Shape of Dogs" by Elaine Ostrander.
The panel shown here reveals the details in the structure of sequence similarity between each dog chromosome and the human genome (top) and each human chromosome and the dog genome (bottom).
Circos Sniffs out Dog Genetics in American Scientist
The completion of the draft version of the dog genome revealed large overlaps between dog and human genomes. Working with American Scientist, Martin Krzywinski generated an illustration showing blocks of similarity between the two genomes.
The illustration accompanies the article Genetics and the Shape of Dogs, by Elaine Ostrander.
NYT Article - Mapping the Epigenome
In collaboration with Jonathan Corum from the NYT, Martin Krzywinski created an illustration of data showing methylation on chromosome 22 in a variety of tissues.
The illustration accompanies the article Now: The Rest of the Genome, by Carl Zimmer.
Guide to Displaying Sequence Conservation Across Species
This poster shows how Circos can be used to display sequence similarity and conservation. The inner ribbon track is used to show synteny and exterior tracks quantify the degree of sequence conservation between the human genome and 7 other species.
This guide demonstrates the use of the convential chromosome color palette, in which each of the human chromosomes, as well as well as chrUn (unanchored sequence), is assigned a characteristic color. Also shown are ways in which 2D track types (text, stacked histogram, highlight, heatmap) can be used to add texture to the data or display summary statistics.
